Given the continuous political and social instability in the ESCWA region and the inadequate socio-economic development policies that have been implemented, Western Asia is in danger of becoming more vulnerable to poverty than ever before. Alleviating poverty can be achieved by encouraging entrepreneurial activities and establishing small and macro enterprises. This study focuses on the alleviation of poverty in the region through ICTs that can empower the poor and develop entrepreneurial activities. The study targets policymakers, non-governmental organizations (NGOs) and Governments. It reviews case studies on alleviating poverty, presents frameworks and recommends policies.