Trade facilitation plays a significant role in improving trade growth and competitiveness within the context of the global supply chain. This report sheds light on the requirements for establishing the Single Window system for trade facilitation. Having defined the Single Window system, the report provides comprehensive information on the compliance of national trade policies with trade treaties, trade law and trade regulations. It also analyses initiatives in ESCWA member countries to establish the Single Window system with a view to highlighting best practice across the region. The report concludes with a number of policy recommendations addressed to ESCWA member countries and to the Commission.