In 2010, the Commission intensified its efforts towards the achievement of regional economic and social integration, as well as greater interaction between the region and the rest of the world. In response to the global challenges and events of recent years, ESCWA continued to serve the region through its programme of work, which comprises seven subprogrammes: integrated management of natural resources for sustainable development; integrated social policies; economic development and integration; information and communications technology for regional integration; statistics for evidence-based policymaking; advancement of women; and conflict mitigation and development. The Annual Report 2010 reviews the accomplishments of ESCWA. It also offers an overview of the challenges and opportunities in related areas of concern, namely the Millennium Development Goals; youth; renewable energy; the information society; the global economic and financial crisis; and the empowerment of women. The Report concludes with a perspective on the way ahead and the imminent challenging agenda, emphasizing the continuous commitment of ESCWA to the sustainable development agenda.